Yasynska E. Analysis of the opinions of health care managers at different levels on the reorganization of the primary and secondary health care links // International scientific journal "Internauka". — 2023. — №12. https://doi.org/10.25313/2520-2057-2023-12-9025

Summary: It is shown that a daily intake of MSG at a dose of 30 mg / kg body weight for 28 days led to increased glucose and glucose-6-phosphatase activity and reduced lactate and lactic-dehydrogenase activity at a constant level of glycogen in the rats’ liver, which may indicate metabolic changes in the glucose metabolism.

Key words: MSG, carbohydrate metabolism, liver, rats.

Summary.  Experiments on 40 white non-linear immature (l-month old) male rats evaluated  indices of  renal function with sublimate nephropathy at loading by 3% sodium chloride solution in volume of 5% of the body weight under conditions of  blockade of renal prostaglandins production with indomethacin and had shown inhibition of diuresis, decrease of sign of the syndrome of sodium ions loss with urine against the background of hypernatremia. Disorders of glomerular-tubular balance were characterized by the loss of positive correlative dependences of relative reabsorption of water with  glomerular filtration, filtrative fraction and absolute reabsorption of sodium ions. The defined changes in glomerular-tubular balance in sexually immature rats with sublimate nephropathy under the 3% solution of sodium chloride loading to the extent of 5% of body mass under the condition of blocking the production of kidney prostaglandins by indomethacin with the loss of positive correlation dependence of the relative water reabsorption on glomerular filtration, filtration fraction and absolute reabsorption of sodium ions, confirm the effect of the prostaglandins on the above processes in immature rats. The decrease of the compensatory abilities as to the development of the syndrome of sodium ions loss in immature rats in experiment leads to the disorders of sodium homeostasis and to the development of hypernatraemia.

Key words: sublimate nephropathy, loading by 3% sodium chloride solution, indomethacin, immature rats.

Summary: From the positions of probative medicine the work presents theoretical substantiation and a new approach to solve the scientific task concerning early pathogenesis mechanisms of pseudohepatorenal syndrome as the basis to deteriorate the course of kidney and liver failure with breaking oxidative phosphorylation under conditions of 2,4-dinitrofenol administration. The experiments were conducted on 120 albino outbred male rats with the body weight of 0,16-0,20 kg fed on low-sodium diet with tissue hypoxia modeling.

Key words: 2,4-dinitrofenol, kidneys, liver, cytokines, sodium ions loss syndrome, melatonin, oxidative modified proteins.