Summary. This article presents analysis the development of foreign economic activity of regions of Ukraine for the period 2012-2015. Discovered reorientation of the export vector regions of Ukraine during the study period and change from the usual markets with new ones. Due to structural changes in the proportions of foreign trade of Ukraine's regions identified key problems of development of foreign economic relations. An analysis of proposed guidelines for central government to address the problems identified structural imbalances and regulation of foreign economic activity of regions of Ukraine.
Keywords: structural imbalances, gross domestic product, exports, imports, foreign trade.