Abstract. It was studied a puberty of 1078 school age boys residing in 6 cities of Uzbekistan and Karakalpakstan by somatoscopy method. It was revealed that Karakalpak boys were far behind development pace of the main puberty signs (pubic area pilosis) from their peers of Tashkent and other cities of Uzbekistan. Dynamic observation at 18-years period (1999 and 2016) was showed no difference in a sexual development of Uzbeks boys. While over 39-years period (1978-2016 years) in Karakalpak boys an average age of an appearance of pubic hair pilosis began to 1 year and 5 months before.

Keywords: puberty, secondary sexual characteristics, age norms.

Summary. The clinical features and associated symptoms of post-traumatic mental disorders in combatants were investigated.

Keywords: post-traumatic mental disorders, adjustment disorders, participants of ATO, clinical features.

Abstract. Nowadays cardio-vascular diseases are the leading reasons of mortality and disability. The well-timed and correct diagnostic of these diseases is based on the control of the parameters of the functional state of the cardiovascular system, including monitoring in prolonged uninterrupted mode. There are different modern technologies for diagnostic and treatment interpretation which can reduce the number of visits to the doctor. So, these systems ought to meet several criteria, such as data channel with opportunity to translate messages about life-threatening events. Complex of all these advances will allow optimize and personalize treatment and management algorithms.

Keywords: information interface, the cardiovascular system, control of parameters.

Summary. The impact of retrograde caval reperfusion on the risk and the severity of early allograft dysfunction were performed in this study.

Keywords: retrograde caval reperfusion, early allograft dysfunction, liver transplantation.

Summary. In the article data demonstrated modern literature data with you, teaching pathogenesis, clinical presentation, diagnosis and treatment of advanced forms Adrenogenital syndrome.

Keywords: adrenogenital syndrome, corticosteroids, adrenal gland, hyperplasia, heredity.

Summary: The comparison of spinal analgesia and obstetric sleep and their effect on delivery process and the baby.

Key words: labor analgesia, obstetric sleep, spinal analgesia. 

Abstract: Using several techniques the article discusses issues of mental and emotional state of patients in emergency department. The study in GU «Central Hospital» of Rybnitsa found, that patients being treated in the department of anesthesiology, emergency and intensive care often have a variety of negative emotional states, the degree of which varies depending on the frequency of being in departament.

Keywords: intensive care unit, patients, emergency department, psycho-emotional state.

Summary: explore alternative methods of a multimodal anesthesia anetsezii in patients undergoing surgery of high trauma to the digestive tract

Keywords: pain; electroanalgesia; nefopam.

Abstract. The paper presents the clinical and neuropsychological features in the middle aged adults - University staff living in the climate-geographic conditions of the Kyrgyz Republic, Bishkek. The examined individuals suffered from physical inactivity, violation of the mode of consumption of food, liquid, sleep disorders, accompanied by of the neurological symptoms and somatic diseases. High trait anxiety was diagnosed in 58,1% and depression in 54,8% of the teachers. In one third of patients physical fatigue with a decrease in daily activity was diagnosed.

Key words: clinical and neuropsychological features, middle aged adults, climatic and geographical conditions.

Abstract: The paper deals with the treatment of alcohol poisoning in the elderly, particular attention is paid to specific features of treatment of this disease. During the research in the State institution «Rybnitsa Central Hospital» it was found that the reaction to the poisoning occurs in elderly patients with specific characteristics and possible complications that require individual correction of the treatment.

Keywords: the elderly, alcohol poisoning, monitoring, treatment.

Abstract: we investigate theoretical questions about the culture of medical education as a factor of improving the quality of medical services in the region.

Keywords: medical care, medical services, culture of medical care.

Abstract. Questions of public health in Uzbekistan, its well-being is a priority for the Government of the Republic of Uzbekistan.

The successes achieved in the fight against infectious and parasitic diseases, in many ways, are a result of the activities carried out in recent years. A conscious attitude and a thorough implementation of the requirements of the medical staff of preventive and anti-epidemic regime in health care facilities prevent the incidence of professional staff, and will also contribute to the prevention of disease of nosocomial infections in patients.

Keywords: hemodialysis, hospital infection , disinfection , anti-epidemic regime .

Резюме. Осложнения раннего неонатального периода у новорожденных от матерей с острыми вирусными гепатитами встречаются достоверно чаще, чем в группе контроля. Среди детей, родившихся от матерей с ОВГВ выявлены более низкие показатели физического развития и повышенная заболеваемость в первые дни жизни. Перинатальная гипотрофия составила 16,7%. При ОВГС у матери чрезвычайно высокой была частота встречаемости внутриутробной инфекции (до 25,2%). Асфиксия у новорожденных группы сравнения встречалась в 5,5 раза чаще, чем в группе контроля.

Ключевые слова: острый вирусный гепатит, родильницы, новорожденные.

Abstract. A comparative study of the dynamics of increase in the longitudinal size and body mass in healthy newborns (848 people). in children with asymmetric intrauterine growth retardation (IUGR, 886 people)., who at the time of birth to the term body weight was below the norm by 22% in 28 patients with cerebral palsy, and in 30 patients with congenital lag in the growth of one of the lower extremities. In subsequent years, the rate of longitudinal growth of the body in patients of all groups did not differ from the norm, whereas IUGR observed slowdown in the pace of weight gain and head circumference of 1-2 cm, as well as indicators of functional maturation of children.  After 6 years after the birth of children with consequences of IUGR main indicators of mental development close to those of healthy peers.  The incidence and severity of IUGR increases at deterioration of the economic situation of the region's population , while reducing the systemic blood pressure in women. Revealed a genetic predisposition to the appearance of this pathology.

 Keywords: newborns, body length,  anthropometry, abnormal development.

Annotation. Stand presented hygienic justification for the development of water supply schemes and improving the quality of drinking water , the comparative sanitary- hygienic characteristics of the water quality of water bodies and water tap in Surkhandarya , Khorezm regions and the whole country .

Keywords: quality of drinking water , hygienic substantiation to the schemes of water supply , security , prevention of infectious diseases.

Annotation. The material provides data on toxicological and hygienic assessment  new cotton defoliant "UzDEF-K." It was found that the preparat is a low-hazard compound belongs to IV class of danger. Designed hygienic standards in the environment and food products (MPC in water bodies of water , in the air of the working area and the atmosphere air; MRLs in food, soil UEC ) . Science-based regulations of safe use of the drug in the agrifarms - sanitary protection zone, time-to-work.

Keywords: pesticide, hygienic standard, defoliant " UzDEF-K", the environment, water, air, soil, food products.

Abstract. With the development of hemorrhagic shock due to a drop in blood pressure, blood flow slows down. Perfusion of vital organs deteriorate. All this leads to hypoxia, decreased pH, appear stasis develops hemorheology severe pathology. The article examines the dynamics of physical (rheological) properties of blood depending on the amount of blood loss.

Keywords: physical (rheological) properties of blood, blood viscosity, erythrocyte aggregation.

Summary.  Experiments on 40 white non-linear immature (l-month old) male rats evaluated  indices of  renal function with sublimate nephropathy at loading by 3% sodium chloride solution in volume of 5% of the body weight under conditions of  blockade of renal prostaglandins production with indomethacin and had shown inhibition of diuresis, decrease of sign of the syndrome of sodium ions loss with urine against the background of hypernatremia. Disorders of glomerular-tubular balance were characterized by the loss of positive correlative dependences of relative reabsorption of water with  glomerular filtration, filtrative fraction and absolute reabsorption of sodium ions. The defined changes in glomerular-tubular balance in sexually immature rats with sublimate nephropathy under the 3% solution of sodium chloride loading to the extent of 5% of body mass under the condition of blocking the production of kidney prostaglandins by indomethacin with the loss of positive correlation dependence of the relative water reabsorption on glomerular filtration, filtration fraction and absolute reabsorption of sodium ions, confirm the effect of the prostaglandins on the above processes in immature rats. The decrease of the compensatory abilities as to the development of the syndrome of sodium ions loss in immature rats in experiment leads to the disorders of sodium homeostasis and to the development of hypernatraemia.

Key words: sublimate nephropathy, loading by 3% sodium chloride solution, indomethacin, immature rats.

Summary: The results of clinical and diagnostic examination and treatment of 93 children with atopic dermatitis (AD), living in the south of the Kyrgyz Republic. It was determined:  high level availability of family history of examined children, elevated levels of total IgE in serum, comorbidities. It was confirmed the effectiveness of the combination treatment of AD, including antihistamines, first-and second-generation topical and systemic corticosteroids, antibiotics, diet and physical therapy. The necessities of recurrence treatment and long-term individual follow-up were proved.

Key words: children, atopic dermatitis, antihistamines, antibiotic therapy, corticosteroids, diet therapy.