Features of the effect of the dietary supplement "NEPHROBIOTIC" on inflammatory markers, nitrogenous uremic toxins, and the condition of the gastrointestinal tract in patients with chronic kidney failure

Анотація

The article is dedicated to the study of methods for effectively removing uremic toxins in patients with chronic kidney failure and the development of a probiotic that influences this process. The study aimed to develop the dietary supplement "NEPHROBIOTIC" and determine its effect on inflammatory markers, nitrogenous uremic toxins, and the condition of the gastrointestinal tract in patients with chronic kidney failure. Materials and methods. During the development and study of the dietary supplement "NEPHROBIOTIC," a combination of lacto- and bifidobacteria was used, including three probiotic strains of beneficial bacteria: Streptococcus thermophilus (IMB B-8116), Lactobacillus acidophilus (IMB B-8117), and Bifidobacterium longum (IMB B-8118). Results and discussion. It has been demonstrated that chronic kidney disease may be accompanied by the development of intestinal inflammation and disruption of the epithelial barrier, leading to accelerated systemic translocation of bacterialorigin uremic toxins. These discoveries have provided new therapeutic opportunities for treating uremia, including prebiotics, probiotics, and synbiotics. The study showed that the developed dietary supplement "NEPHROBIOTIC" could metabolise urea in human urine from 41.56% to 80.38%. "NEPHROBIOTIC" contains three live probiotic cultures: Bifidobacterium longum IMB B-8118, Lactobacillus acidophilus IMB B-8117, and Streptococcus thermophilus IMB B-8116. It was established that individual pure live cultures (monocultures) exhibited a limited ability to metabolise urea: 80.38% (Bifidobacterium longum IMB B-8118), 51.24% (Streptococcus thermophilus IMB B-8116), and 49.0% (Lactobacillus acidophilus IMB B-8117). The mixture of three pure cultures demonstrated a lower ability to metabolise urea – 41.56%. Conclusion. The dietary supplement "NEPHROBIOTIC" may be recommended as part of the diet as an additional source of biologically active substances to support the beneficial effects of probiotics on inflammatory markers, protein-bound nitrogenous uremic toxins, and gastrointestinal symptoms in patients with chronic kidney failure.

Ключові слова: nephrology; urea metabolism; probiotic; microflora; development; treatment

Як цитувати

@article{internauka10731,
  author   = {Черній, Володимир Петрович and Черній, Андрій Петрович},
  title    = {Features of the effect of the dietary supplement "NEPHROBIOTIC" on inflammatory markers, nitrogenous uremic toxins, and the condition of the gastrointestinal tract in patients with chronic kidney failure},
  journal  = {Міжнародний науковий журнал «Інтернаука»},
  year     = {2025},
  number   = {2},
  doi      = {10.25313/2520-2057-2025-2-10731},
  url      = {https://www.inter-nauka.com/issues/2025/2/10731}
}

TY  - JOUR
AU  - Черній, Володимир Петрович
AU  - Черній, Андрій Петрович
TI  - Features of the effect of the dietary supplement "NEPHROBIOTIC" on inflammatory markers, nitrogenous uremic toxins, and the condition of the gastrointestinal tract in patients with chronic kidney failure
JO  - Міжнародний науковий журнал «Інтернаука»
PY  - 2025
IS  - 2
SN  - 2520-2057
DO  - 10.25313/2520-2057-2025-2-10731
UR  - https://www.inter-nauka.com/issues/2025/2/10731
LA  - en
ER  -